Bitiron T3 and T4 Mix (12.5mcg/50mcg)

Bitiron is a synthetic formulation for thyroid hormone replacement therapy. It combines Levothyroxine Sodium (Thyroxine, T4) and Liothyronine Sodium (Triiodothyronine, T3) in a 4 to 1 weight ratio. Bitiron was created based on the assumption that both T4 and T3 levels in the serum were directly regulated by thyroid secretion. Current understanding reveals that the thyroid gland produces approximately ten times more T4 than T3, with 80% of serum T3 resulting from the conversion of T4 in peripheral tissues. For most patients, administering Levothyroxine alone is adequate for sustaining serum T4 and T3 levels, and combination hormone therapy typically does not provide any therapeutic benefits. In fact, using T3 could lead to excessively high levels of T3.

Thyroid hormone medications are either natural or synthetic and may contain T4, T3, or both. The human thyroid gland synthesizes T4 and T3 through the iodination and coupling of the amino acid tyrosine. Bitiron is a synthetic formulation of T4 and T3 in a 4:1 weight ratio. These hormones boost oxygen consumption in most bodily tissues, increase the basal metabolic rate, and enhance the metabolism of carbohydrates, lipids, and proteins. As a result, they significantly impact every organ system and play a crucial role in the development of the central nervous system.

T4 and T3 are hormones based on tyrosine that are produced in the thyroid gland, with iodine being a vital component for their synthesis. The primary form of thyroid hormone released is T4, which is converted to T3, the more potent thyroid hormone, by deiodinases in peripheral tissues. T3 functions in the body to elevate the basal metabolic rate, modify protein synthesis, and enhance sensitivity to catecholamines (such as adrenaline). Thyroid hormones are vital for the proper growth and differentiation of all human cells. They regulate the metabolism of proteins, fats, and carbohydrates to varying degrees. The most significant effect of these hormones is on how human cells utilize energetic compounds. Thyroid hormone derivatives first bind to the thyroid hormone receptors, triggering their subsequent effects.